Milling involves the application of mechanical energy to physically break down coarse
particles to finer ones and is regarded as a “top–down” approach in the production of fine …

Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …

Drug nanocrystals are a versatile option for drug delivery purposes, and while the number of
poorly soluble drug materials is all the time increasing, more research in this area is …

Preparation of drug nanoparticles via wet media milling (nanomilling) is a very versatile drug
delivery platform and is suitable for oral, injectable, inhalable, and buccal applications. Wet …

Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in
terms of molecular weights and viscosity grades is the basis for its wide and successful …

Intravitreal injections (IVT) are regarded as the gold standard for effective delivery of
hydrophobic drugs to the back of the eye. However, as a highly invasive procedure, the …

The design and feasibility of a simple process of incorporating stable nanoparticles into
edible polymer films is demonstrated with the goal of enhancing the dissolution rate of …

The purpose of this study was to develop nanosuspension formulations of a poorly soluble
drug using a wet media milling technique. The milling process was optimized by studying …

Wet media milling is a popular technology used to prepare nanosuspensions. However, the
theories and methods to guide the research on the formulation and process affecting wet …