For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

The clinical diagnosis of Parkinson's disease rests on the identification of the characteristics
related to dopamine deficiency that are a consequence of degeneration of the substantia …

Depression is the most frequent psychiatric comorbidity in people with epilepsy (PWE) with
lifetime prevalence rates ranging between 30 and 35%. Multifactorial variables play a …

There is convincing evidence that the Parkinson disease neurodegenerative process begins
many years before the onset of motor manifestations. Initial estimates based on nigral …

Over the past 15 years the use of transcranial B-mode sonography to assess brainstem and
subcortical brain structures has become an important tool for the diagnosis and differential …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Objective: To investigate the long-term risk of Parkinson disease (PD) after depression and
evaluate potential confounding by shared susceptibility to the 2 diagnoses. Methods: The …

Objective: To investigate the associations between Parkinson's disease and other
degenerative parkinsonian syndromes and environmental factors in five European …