Introduction: Lentiviruses are a very potent class of viral vectors for which there is presently a
rapidly growing interest for a number of gene therapy. However, their construction …

The past decade witnessed the entry into the market of new virus-based biopharmaceuticals
produced in animal cells such as oncolytic vectors, virus-like particle vaccines, and gene …

The use of lentiviral vectors (LV) in gene therapy has been growing in recent years. To meet
the increasing clinical demand, LV production platforms will benefit from improved …

Biopharmaceuticals derived from enveloped virus comprise an expanding market of
vaccines, oncolytic vectors and gene therapy products. Thus, increased attention is given to …

The development of lentiviral-based therapeutics is challenged by the high cost of current
Good Manufacturing Practices (cGMP) production. Lentiviruses are enveloped viruses that …

Many mammalian cell lines used in the manufacturing of biopharmaceuticals exhibit high
glycolytic flux predominantly channeled to the production of lactate. The accumulation of …

Virus-like particles (VLPs) are a particular subset of subunit vaccines which are currently
explored as safer alternatives to live attenuated or inactivated vaccines. VLPs derived from …

This article describes a novel method merging the cloning of viral vector producer cells with
vector titer screening, allowing for screening 200–500 clones in 2 weeks. It makes use of a …

Hepatitis C pseudoparticles (HCVpp) are used to evaluate HCV cell entry while screening
for neutralizing antibodies induced upon vaccination or while screening for new antiviral …

Background: β-secretase (BACE1) is a type 1 transmembrane protein implicated in
Alzheimer's Disease (AD) pathogenesis. Cleavage of Amyloid Precursor Protein (APP) …