The roles of Par3, Par6, and aPKC polarity proteins in normal neurodevelopment and in neurodegenerative and neuropsychiatric disorders
L Zhang, X Wei - Journal of Neuroscience, 2022 - Soc Neuroscience
Normal neural circuits and functions depend on proper neuronal differentiation, migration,
synaptic plasticity, and maintenance. Abnormalities in these processes underlie various …
synaptic plasticity, and maintenance. Abnormalities in these processes underlie various …
[HTML][HTML] The role of contactin-associated protein-like 2 in neurodevelopmental disease and human cerebral cortex evolution
F St. George-Hyslop, T Kivisild… - Frontiers in Molecular …, 2022 - frontiersin.org
The contactin-associated protein-like 2 (CNTNAP2) gene is associated with multiple
neurodevelopmental disorders, including autism spectrum disorder (ASD), intellectual …
neurodevelopmental disorders, including autism spectrum disorder (ASD), intellectual …
[HTML][HTML] Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
Although many neuronal membrane proteins undergo proteolytic cleavage, little is known
about the biological significance of neuronal ectodomain shedding (ES). Here, we show that …
about the biological significance of neuronal ectodomain shedding (ES). Here, we show that …
[HTML][HTML] Assembly and function of the juxtaparanodal Kv1 complex in health and disease
D Pinatel, C Faivre-Sarrailh - Life, 2020 - mdpi.com
The precise axonal distribution of specific potassium channels is known to secure the shape
and frequency of action potentials in myelinated fibers. The low-threshold voltage-gated Kv1 …
and frequency of action potentials in myelinated fibers. The low-threshold voltage-gated Kv1 …
[HTML][HTML] Altered Expression of Par3, aPKC-λ, and Lgl1 in hippocampus in kainic acid-induced status epilepticus rat model
C Zhang, F Tian, Z Tan, J Du, X Long - Frontiers in Neurology, 2021 - frontiersin.org
Introduction: Mossy fiber sprouting (MFS) is a frequent histopathological finding in temporal
lobe epilepsy (TLE) and is involved in the pathology of TLE. However, molecular signals …
lobe epilepsy (TLE) and is involved in the pathology of TLE. However, molecular signals …
[HTML][HTML] The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models
V Meliskova, T Havranek, Z Bacova… - Journal of Integrative …, 2021 - imrpress.com
Pathological changes in synapse formation, plasticity and development are caused by
altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic …
altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic …