The prevalence of osteoarthritis (OA) and the burden associated with the disease are
steadily increasing worldwide, representing a major public health challenge for the coming …

The regulation of body temperature is one of the most critical functions of the nervous
system. Here we review our current understanding of thermoregulation in mammals. We …

Many transient receptor potential (TRP) channels respond to diverse stimuli and
conditionally conduct small and large cations. Such functional plasticity is presumably …

Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

Maintenance of a homeostatic body core temperature is a critical brain function
accomplished by a central neural network. This orchestrates a complex behavioral and …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Neuroimmunology is one of the fastest-growing fields in the life sciences, and for good
reason; it fills the gap between two principal systems of the organism, the nervous system …

The primary sensory system requires the integrated function of multiple cell types, although
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …