Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …

Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood.
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …

Complement is an innate immune system that is a first line of defense against pathogens
and facilitates elimination of apoptotic and injured cells. During complement activation, the …

Previous trials indicate that surgical management of small abdominal aortic aneurysms
(AAA) does not reduce mortality. The medical management of AAA, however, has to a large …

Thoracic aortic dissection (TAD) is a catastrophic disease with high mortality and morbidity,
characterized by fragmentation of elastin and loss of smooth muscle cells. However, the …

Objective—We previously established that neutrophil-derived dipeptidyl peptidase I (DPPI)
is essential for experimental abdominal aortic aneurysm (AAA) development. Because DPPI …

The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks of
atherosclerotic and atherothrombotic disease, but comprises an additional, predominant …

Cerebral aneurysms (CAs) occur in up to 5% of the population in the US, and up to 7% of all
strokes are caused by CA rupture. Little is known about the pathophysiology of cerebral …

Neutrophil serine proteases: mediators of innate immune resp... : Current Opinion in
Hematology Neutrophil serine proteases: mediators of innate immune responses : Current …