Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in adults and
is characterized by neurodegeneration of motor neurons in the brain and spinal cord. The …

Amyotrophic lateral sclerosis (ALS) is a progressive, degenerative neuromuscular disease
with limited treatment options. The diagnosis of ALS can be challenging for numerous …

Objective This guideline provides evidence-based recommendations on treating patients
who present with dysphonia, which is characterized by altered vocal quality, pitch, loudness …

Objective To evaluate neurofilament light (NfL) as a biomarker of the presymptomatic phase
of amyotrophic lateral sclerosis (ALS). Methods The study population includes 84 individuals …

Objective To determine the diagnostic and prognostic performance of serum neurofilament
light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease in
which many processes are detected including (neuro) inflammation. Many drugs have been …

Cortical dysfunction—specifically, the development of hyperexcitability—seems to be an
early and intrinsic feature of sporadic and familial amyotrophic lateral sclerosis (ALS) …

Current research efforts on neurological diseases are focused on identifying novel disease
biomarkers to aid in diagnosis, provide accurate prognostic information and monitor disease …

Since the discovery of Cu/Zn superoxide dismutase (SOD1) gene mutation, in 1993, as the
first genetic abnormality in amyotrophic lateral sclerosis (ALS), over 50 genes have been …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, leading to
death within an average of 2–3 years. A cure is yet to be found, and a single disease …