Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

Genomics and the future of conservation genetics

FW Allendorf, PA Hohenlohe, G Luikart - Nature reviews genetics, 2010 - nature.com
We will soon have complete genome sequences from thousands of species, as well as from
many individuals within species. This coming explosion of information will transform our …

Mapping genes for complex traits in domestic animals and their use in breeding programmes

ME Goddard, BJ Hayes - Nature Reviews Genetics, 2009 - nature.com
Genome-wide panels of SNPs have recently been used in domestic animal species to map
and identify genes for many traits and to select genetically desirable livestock. This has led …

Genomics advances the study of inbreeding depression in the wild

M Kardos, HR Taylor, H Ellegren… - Evolutionary …, 2016 - Wiley Online Library
Inbreeding depression (reduced fitness of individuals with related parents) has long been a
major focus of ecology, evolution, and conservation biology. Despite decades of research …

The future of livestock breeding: genomic selection for efficiency, reduced emissions intensity, and adaptation

BJ Hayes, HA Lewin, ME Goddard - Trends in genetics, 2013 - cell.com
As the global population and global wealth both continue to increase, so will the demand for
livestock products, especially those that are highly nutritious. However, competition with …

Endoplasmic-reticulum calcium depletion and disease

D Mekahli, G Bultynck, JB Parys… - Cold Spring …, 2011 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …

Calcium pumps in health and disease

M Brini, E Carafoli - Physiological reviews, 2009 - journals.physiology.org
Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

The future of ancient DNA: technical advances and conceptual shifts

M Hofreiter, JLA Paijmans, H Goodchild… - …, 2015 - Wiley Online Library
Technological innovations such as next generation sequencing and DNA hybridisation
enrichment have resulted in multi‐fold increases in both the quantity of ancient DNA …

[HTML][HTML] Harmful recessive effects on fertility detected by absence of homozygous haplotypes

PM VanRaden, KM Olson, DJ Null, JL Hutchison - Journal of dairy science, 2011 - Elsevier
Five new recessive defects were discovered in Holsteins, Jerseys, and Brown Swiss by
examining haplotypes that had a high population frequency but were never homozygous …

Inbreeding depression in livestock species: review and meta‐analysis

G Leroy - Animal genetics, 2014 - Wiley Online Library
Inbreeding, by virtue of its consequence on traits of interest, is a topic of major interest for
geneticists and animal breeders. Based on meta‐analysis conducted on 57 studies and …