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G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and
are critically involved in the regulation of different mitogen-activated protein kinase (MAPK) …

Linker or adapter proteins provide mechanisms by which receptors can amplify and regulate
downstream effector proteins. We describe here the identification of a novel B cell linker …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

THE oncogenic protein Vav1, 2 harbours a complex array of structural motifs, including
leucine-rich, Dbl-homology, pleckstrin-homology, zinc-finger, SH2 and SH3 domains. Upon …

The GTP hydrolases of the Rho/Rac family participate in the generation of coordinated
cellular responses to extracellular stimuli (52, 153). Their actions are essential to promote …

Rho-family GTPases transduce signals from receptors leading to changes in cell shape and
motility, mitogenesis, and development. Proteins containing the Dbl homology (DH) domain …

In recent years, substantial progress has been made towards the identification of
intracellular signalling molecules that couple multi-subunit immune-recognition receptors …

Background: Vav is a guanine-nucleotide exchange factor for the Rho-like small GTPases
RhoA, Rac1 and Cdc42, which regulate cytoskeletal reorganization and activation of stress …

Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide
exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to …