Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Current findings and perspectives on aberrant neural oscillations in schizophrenia
Y Hirano, PJ Uhlhaas - Psychiatry and clinical neurosciences, 2021 - Wiley Online Library
There is now consistent evidence that neural oscillation at low‐and high‐frequencies
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …
constitute an important aspect of the pathophysiology of schizophrenia. Specifically …
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Ketamine's mechanism of action was assessed using gamma power from
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
magnetoencephalography (MEG) as a proxy measure for homeostatic balance in 35 …
Dysregulation of midbrain dopamine system and the pathophysiology of schizophrenia
Dysregulation of the dopamine system is central to many models of the pathophysiology of
psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is …
psychosis in schizophrenia. However, emerging evidence suggests that this dysregulation is …
Impaired tuning of neural ensembles and the pathophysiology of schizophrenia: a translational and computational neuroscience perspective
The functional optimization of neural ensembles is central to human higher cognitive
functions. When the functions through which neural activity is tuned fail to develop or break …
functions. When the functions through which neural activity is tuned fail to develop or break …
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
P Zanos, JN Highland, BW Stewart… - Proceedings of the …, 2019 - National Acad Sciences
Currently approved antidepressant drugs often take months to take full effect, and∼ 30% of
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …
[HTML][HTML] Computational modeling of electroencephalography and functional magnetic resonance imaging paradigms indicates a consistent loss of pyramidal cell …
Background Diminished synaptic gain—the sensitivity of postsynaptic responses to neural
inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is …
inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is …
[HTML][HTML] An update on the use of gamma (multi) sensory stimulation for Alzheimer's disease treatment
Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma
band (γ,> 30 Hz). Several animal studies show that inducing gamma oscillations through …
band (γ,> 30 Hz). Several animal studies show that inducing gamma oscillations through …
Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression
Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
Cognitive and neuropathophysiological outcomes of gamma-tACS in dementia: a systematic review
Despite the numerous pharmacological interventions targeting dementia, no disease-
modifying therapy is available, and the prognosis remains unfavorable. A promising …
modifying therapy is available, and the prognosis remains unfavorable. A promising …