HIV-1 drug resistance and resistance testing
DS Clutter, MR Jordan, S Bertagnolio… - Infection, Genetics and …, 2016 - Elsevier
The global scale-up of antiretroviral (ARV) therapy (ART) has led to dramatic reductions in
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …
HIV-1 mortality and incidence. However, HIV drug resistance (HIVDR) poses a potential …
Structural basis of coreceptor recognition by HIV-1 envelope spike
MM Shaik, H Peng, J Lu, S Rits-Volloch, C Xu, M Liao… - Nature, 2019 - nature.com
Abstract HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) 3 cleaved to
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …
Co-receptor signaling in the pathogenesis of neuroHIV
EA Nickoloff-Bybel, L Festa, O Meucci, PJ Gaskill - Retrovirology, 2021 - Springer
The HIV co-receptors, CCR5 and CXCR4, are necessary for HIV entry into target cells,
interacting with the HIV envelope protein, gp120, to initiate several signaling cascades …
interacting with the HIV envelope protein, gp120, to initiate several signaling cascades …
[HTML][HTML] Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method
Abstract The World Health Organization (WHO) introduced “Coronavirus disease 19” or
“COVID-19” as a novel coronavirus in March 2020. Severe acute respiratory syndrome …
“COVID-19” as a novel coronavirus in March 2020. Severe acute respiratory syndrome …
Specific mutations in the HIV-1 G-tract of the 3′-polypurine tract cause resistance to integrase strand transfer inhibitors
A Hachiya, M Kubota, U Shigemi, H Ode… - Journal of …, 2022 - academic.oup.com
Background In vitro selection experiments identified viruses resistant to integrase strand
transfer inhibitors (INSTIs) carrying mutations in the G-tract (six guanosines) of the 3 …
transfer inhibitors (INSTIs) carrying mutations in the G-tract (six guanosines) of the 3 …
Deep Sequencing of the HIV-1 env Gene Reveals Discrete X4 Lineages and Linkage Disequilibrium between X4 and R5 Viruses in the V1/V2 and V3 Variable …
ABSTRACT HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or
CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either …
CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either …
Identification of the natural product berberine as an antiviral drug
J Shao, D Zeng, S Tian, G Liu, J Fu - AMB Express, 2020 - Springer
Drugs targeting the fusion process of viral entry into host cells have been approved for
clinical use in the treatment of AIDS. There remains a great need to improve the use of …
clinical use in the treatment of AIDS. There remains a great need to improve the use of …
Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015)
W Li, L Lu, W Li, S Jiang - Expert opinion on therapeutic patents, 2017 - Taylor & Francis
Introduction: It is essential to discover and develop small-molecule HIV-1 entry inhibitors
with suitable pharmaceutical properties. Areas covered: We review the development of small …
with suitable pharmaceutical properties. Areas covered: We review the development of small …
Mapping biological process relationships and disease perturbations within a pathway network
R Stoney, DL Robertson, G Nenadic… - NPJ systems biology …, 2018 - nature.com
Molecular interaction networks are routinely used to map the organization of cellular
function. Edges represent interactions between genes, proteins, or metabolites. However, in …
function. Edges represent interactions between genes, proteins, or metabolites. However, in …
Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model
O DeLeon, H Hodis, Y O'Malley, J Johnson… - PLoS …, 2017 - journals.plos.org
The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random
mutations and recombination events. The resulting diversity of Env variants circulating in the …
mutations and recombination events. The resulting diversity of Env variants circulating in the …