[HTML][HTML] Telomerase and telomeres in aging theory and chronographic aging theory

MP Razgonova, AM Zakharenko… - Molecular …, 2020 - spandidos-publications.com
The current review focuses on the connection of telomerase and telomeres with aging. In
this review, we describe the changes in telomerase and telomere length (TEL) during …

Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex?

SS Jose, K Bendickova, T Kepak, Z Krenova… - Frontiers in …, 2017 - frontiersin.org
Age-related decline in immunity is characterized by stem cell exhaustion, telomere
shortening, and disruption of cell-to-cell communication, leading to increased patient risk of …

Intriguing relationships between cancer and systemic sclerosis: role of the immune system and other contributors

ATJ Maria, L Partouche, R Goulabchand… - Frontiers in …, 2019 - frontiersin.org
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by
multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is …

[HTML][HTML] Telomeres and telomerase in aging, regeneration and cancer

MW Djojosubroto, YS Choi, HW Lee, KL Rudolph - Molecules and cells, 2003 - Elsevier
The finding that telomere shortening limits the replicative lifespan of primary human cells
has fueled speculations that telomere shortening plays a role during aging and regeneration …

Telomerase Activity and Telomere Length in Acute and Chronic Leukemia, Pre- and Post-ex Vivo Culture

M Engelhardt, K Mackenzie, P Drullinsky, RT Silver… - Cancer research, 2000 - AACR
We studied telomerase regulation and telomere length in hematopoietic progenitor cells
from peripheral blood and bone marrow from patients with acute and chronic leukemia and …

Age-related mechanisms in the context of rheumatic disease

G Alsaleh, FC Richter, AK Simon - Nature Reviews Rheumatology, 2022 - nature.com
Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

Telomeres and immunological diseases of aging

NP Andrews, H Fujii, JJ Goronzy, CM Weyand - Gerontology, 2010 - karger.com
A defining feature of the eukaryotic genome is the presence of linear chromosomes. This
arrangement, however, poses several challenges with regard to chromosomal replication …

Telomeres, immune aging and autoimmunity

JJ Goronzy, H Fujii, CM Weyand - Experimental gerontology, 2006 - Elsevier
Telomere length is important in constraining the replicative potential of cells; cellular
systems that are dependent on cell replenishment for renewal or on cell proliferation for …

The telomere/telomerase system in autoimmune and systemic immune-mediated diseases

S Georgin-Lavialle, A Aouba, L Mouthon… - Autoimmunity …, 2010 - Elsevier
Telomeres are specialized nucleoproteic structures that cap and protect the ends of
chromosomes. They can be elongated by the telomerase enzyme, but in telomerase …

[图书][B] Cells, aging, and human disease

MB Fossel - 2004 - books.google.com
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to
clinical application, analyzing the fundamental cellular changes which underlie human age …