Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

Quercetin as an agent for protecting the bone: a review of the current evidence

SK Wong, KY Chin, S Ima-Nirwana - International journal of molecular …, 2020 - mdpi.com
Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide
spectrum of biological activities, thus suggesting a role in disease prevention and health …

Human mesenchymal stem cell derived exosomes enhance cell‐free bone regeneration by altering their miRNAs profiles

M Zhai, Y Zhu, M Yang, C Mao - Advanced Science, 2020 - Wiley Online Library
Implantation of stem cells for tissue regeneration faces significant challenges such as
immune rejection and teratoma formation. Cell‐free tissue regeneration thus has a potential …

Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

E Zengini, K Hatzikotoulas, I Tachmazidou… - Nature …, 2018 - nature.com
Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

A marine terpenoid, heteronemin, induces both the apoptosis and ferroptosis of hepatocellular carcinoma cells and involves the ROS and MAPK pathways

WT Chang, YD Bow, PJ Fu, CY Li… - Oxidative medicine …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a leading cause of death, resulting in over 700 thousand
deaths annually worldwide. Chemotherapy is the primary therapeutic strategy for patients …

Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration …

YH Chan, KN Ho, YC Lee, MJ Chou, WZ Lew… - Stem Cell Research & …, 2022 - Springer
Background Mesenchymal stem cell (MSC)-based tissue engineering plays a major role in
regenerative medicine. However, the efficiency of MSC transplantation and survival of …

Osteogenic differentiation of periosteal cells during fracture healing

T Wang, X Zhang, DD Bikle - Journal of cellular physiology, 2017 - Wiley Online Library
Five to ten percent of fractures fail to heal normally leading to additional surgery, morbidity,
and altered quality of life. Fracture healing involves the coordinated action of stem cells …

Diabetic bone regeneration with nanoceria-tailored scaffolds by recapitulating cellular microenvironment: activating integrin/TGF-β co-signaling of MSCs while …

RK Singh, DS Yoon, N Mandakhbayar, C Li, AG Kurian… - Biomaterials, 2022 - Elsevier
Regenerating defective bone in patients with diabetes mellitus remains a significant
challenge due to high blood glucose level and oxidative stress. Here we aim to tackle this …

Roles of non-canonical Wnt signalling pathways in bone biology

J Lojk, J Marc - International journal of molecular sciences, 2021 - mdpi.com
The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …

Possible mechanisms for the effects of sound vibration on human health

L Bartel, A Mosabbir - Healthcare, 2021 - mdpi.com
This paper presents a narrative review of research literature to “map the landscape” of the
mechanisms of the effect of sound vibration on humans including the physiological …