Introduction Infertility is defined as the inability to conceive after unprotected sexual
intercourse for at least 12 consecutive months. Our objective is to present an updated …

Follicle‐stimulating hormone receptor (FSHR) is a class AG protein‐coupled receptor that
belongs to the subfamily of glycoprotein hormone receptors (GPHRs). The interaction of FSH …

Objective To identify the potential FSHR mutation in a Chinese woman with primary ovarian
insufficiency (POI). Design Genetic and functional studies. Setting University-based …

Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for
reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells …

Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is
essential, in view of its consequences on reproductive health and metabolic disorders in …

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many
cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones …

Premature ovarian insufficiency (POI) is characterized by amenorrhea and elevated levels of
follicle-stimulating hormone (FSH, usually> 25 IU/L) before 40 years of age. To identify the …

Premature ovarian failure (POF) is an insidious cause of female infertility and a devastating
condition for women. POF also has a strong familial and heterogeneous genetic …

Objective To find the genetic etiology of premature ovarian insufficiency (POI) in a patient
with primary amenorrhea and hypergonadotropic hypogonadism. Design Case report …

G protein‐coupled receptors (GPCRs) are central to the functioning of the hypothalamic–
pituitary–gonadal axis (HPG axis) and include the rhodopsin‐like GPCR family members …