The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Tissue-resident macrophages form an essential part of the first line of defense in all tissues
of the body. Next to their immunological role, they play an important role in maintaining …

The mechanisms by which genetic variation affects transcription regulation and phenotypes
at the nucleotide level are incompletely understood. Here we use natural genetic variation …

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue
homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant …

IRF8 and IRF1 are transcriptional regulators that play critical roles in the development and
function of myeloid cells, including activation of macrophages by proinflammatory signals …

Establishing gene regulatory networks during differentiation or reprogramming requires
master or pioneer transcription factors (TFs) such as PU. 1, a prototype master TF of …

The rate at which cells enter the T cell pathway depends not only on the immigration of
hematopoietic precursors into the strong Notch signaling environment of the thymus but also …

Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our
ability to pharmacologically control TF localization is limited. Here we leverage chemically …

The transcription factor PU. 1 is often impaired in patients with acute myeloid leukemia
(AML). Here, we used AML cells that already had low PU. 1 levels and further inhibited PU. 1 …

Macrophages are ubiquitously present innate immune cells in humans and animals
belonging to both invertebrates and vertebrates. These cells were first recognized by Elia …