Major apoptotic mechanisms and genes involved in apoptosis
As much as the cellular viability is important for the living organisms, the elimination of
unnecessary or damaged cells has the opposite necessity for the maintenance of …
unnecessary or damaged cells has the opposite necessity for the maintenance of …
The apoptosome: signalling platform of cell death
SJ Riedl, GS Salvesen - Nature reviews Molecular cell biology, 2007 - nature.com
Recent work on the initial switches that trigger cell death has revealed surprising inventions
of nature that ensure the ordered suicide of a cell that has been selected for demise …
of nature that ensure the ordered suicide of a cell that has been selected for demise …
Apoptosis and cancer: mutations within caspase genes
The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …
but also on the overall integrity of multicellular organisms. Beside developmental …
[HTML][HTML] A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death
LS Dickens, RS Boyd, R Jukes-Jones, MA Hughes… - Molecular cell, 2012 - cell.com
Formation of the death-inducing signaling complex (DISC) is a critical step in death receptor-
mediated apoptosis, yet the mechanisms underlying assembly of this key multiprotein …
mediated apoptosis, yet the mechanisms underlying assembly of this key multiprotein …
Onto better TRAILs for cancer treatment
D de Miguel, J Lemke, A Anel, H Walczak… - Cell Death & …, 2016 - nature.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …
The death domain superfamily in intracellular signaling of apoptosis and inflammation
The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …
effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and …
Apoptosome: a platform for the activation of initiator caspases
Q Bao, Y Shi - Cell Death & Differentiation, 2007 - nature.com
Apoptosome refers to the adaptor protein complex that mediates the activation of an initiator
caspase at the onset of apoptosis. In mammalian cells, caspase-9, caspase-8, and caspase …
caspase at the onset of apoptosis. In mammalian cells, caspase-9, caspase-8, and caspase …
Cell death mechanisms induced by cytotoxic lymphocytes
L Chavez-Galan, AD Angel, E Zenteno… - Cellular & molecular …, 2009 - nature.com
One of the functions of the immune system is to recognize and destroy abnormal or infected
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …
cells to maintain homeostasis. This is accomplished by cytotoxic lymphocytes. Cytotoxicity is …
The Fas–FADD death domain complex structure unravels signalling by receptor clustering
FL Scott, B Stec, C Pop, MK Dobaczewska, JEJ Lee… - Nature, 2009 - nature.com
The death inducing signalling complex (DISC) formed by Fas receptor, FADD (Fas-
associated death domain protein) and caspase 8 is a pivotal trigger of apoptosis,,. The Fas …
associated death domain protein) and caspase 8 is a pivotal trigger of apoptosis,,. The Fas …
E2 interaction and dimerization in the crystal structure of TRAF6
Tumor necrosis factor (TNF) receptor–associated factor (TRAF)-6 mediates Lys63-linked
polyubiquitination for NF-κB activation via its N-terminal RING and zinc finger domains. Here …
polyubiquitination for NF-κB activation via its N-terminal RING and zinc finger domains. Here …