The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …

Enclosed by two membranes, the nucleus itself is comprised of various membraneless
compartments, including nuclear bodies and chromatin domains. These compartments play …

The organization of chromatin into self-interacting domains is universal among eukaryotic
genomes, though how and why they form varies considerably. Here we report a …

Phase separation is emerging as a paradigm to explain the self-assembly and organization
of membraneless bodies in the cell. Recent advances show that this principle also extends …

The eukaryotic genome has a hierarchical three-dimensional (3D) organization with
functional implications for DNA replication, DNA repair, and transcriptional regulation. Over …

Background Although spatial organization of compartments and topologically associating
domains at large scale is relatively well studied, the spatial organization of regulatory …

The genome of a eukaryotic organism is comprised of a supra-molecular complex of
chromatin fibers and intricately folded three-dimensional (3D) structures. Chromosomal …

Abstract Information in the genome is not only encoded within sequence or epigenetic
modifications, but is also found in how it folds in three-dimensional space. The formation of …

Phase separation, a biophysical segregation of subcellular milieus referred as condensates,
is known to regulate transcription, but its impacts on physiological processes are less clear …

Abstract β-actin is a crucial component of several chromatin remodeling complexes that
control chromatin structure and accessibility. The mammalian Brahma-associated factor …