Epigenetics refers to the collection of heritable features that modulate the genome–
environment interaction without being encoded in the actual DNA sequence. While being …

The outcome of older (≥ 60 years) acute myeloid leukemia (AML) patients is poor, and
novel treatments are needed. In a phase 2 trial for older AML patients, low-dose (20 mg/m2 …

Background DNA methylation is a stable epigenetic mark that is frequently altered in tumors.
DNA methylation features are attractive biomarkers for disease states given the stability of …

Background Advances in whole genome profiling have revolutionized the cancer research
field, but at the same time have raised new bioinformatics challenges. For next generation …

Background DNA methylation is an important epigenetic mark and dysregulation of DNA
methylation is associated with many diseases including cancer. Advances in next …

Determining the pattern of methylation at CpG dinucleotides in a cell remains an essential
component of epigenetic profiling. The correlations among methylation, gene expression …

This new volume on gene expression and epigenetics discusses environmental effects
related to specific gene expression. The book also shows methods for bioinformatic analysis …

DNA/RNA-protein interactions are crucial to the maintenance, processing, and regulation of
the genetic information contained within a cell. Sets of particular DNA/RNA-protein …

A decade ago, the Human Genome Project completed the ambitious effort to read the 3
billion DNA letters of genetic information found in most human cells. It provided the blueprint …

The discovery of experience dependent DNA methylation modulation in the brain of adult
organisms revealed a layer of transcriptional control, beyond currently active signaling …