Notch signaling regulates many aspects of metazoan development and tissue renewal.
Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly
associated with gain-of-function mutations in Notch1 that contribute to T-ALL induction and …

The role of the microenvironment in T cell acute lymphoblastic leukemia (T-ALL), or any
acute leukemia, is poorly understood. Here we demonstrate that T-ALL cells are in direct …

Gamma secretase inhibitors (GSIs), initially developed as Alzheimer's therapies, have been
repurposed as anticancer agents given their inhibition of Notch receptor cleavage. The …

Notch signalling participates in the development of multicellular organisms by maintaining
the self-renewal potential of some tissues and inducing the differentiation of others …

Abstract γ-secretase-like proteolysis at site 3 (S3), within the transmembrane domain,
releases the Notch intracellular domain (NICD) and activates CSL-mediated Notch …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system.
In this review, the authors summarize the current knowledge about the impact of the Notch …

Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …