Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and
remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by …

CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous
advantages such as precisely targeting/shearing ability, low cost and convenient operation …

Postmenopausal osteoporosis (PMOP) poses a significant threat to women's health
worldwide. However, detailed molecular mechanism and therapeutic strategy for PMOP …

Background SATB2-associated syndrome (SAS) is a multisystem disorder caused by
mutation of human SATB2 gene. Tooth agenesis is one of the most common phenotypes …

Special AT-rich sequence binding protein-2 (SATB2) is a nuclear matrix protein that binds to
nuclear attachment regions and is involved in chromatin remodeling and transcription …

Background Individuals with pathogenic variants in SATB2 display intellectual disability,
speech and behavioral disorders, dental abnormalities and often features of Pierre Robin …

Abstract SATB2‐associated syndrome (SAS) is an autosomal dominant multisystemic
disorder caused by alterations in the SATB2 gene. In addition to a predominant …

Osteoporosis affects over 200 million women worldwide, one‐third of whom are predicted to
suffer from an osteoporotic fracture in their lifetime. The most promising anabolic drugs …

Limited tissue in biopsies of malignant bone lesions can preclude definitive
subclassification, especially when cellular or matrix elements are sparse, absent, or …

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear
clinically similar but of different histogenesis. The novel marker SATB2 is involved in …