The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
Targeting the DNA damage response in immuno-oncology: developments and opportunities
Immunotherapy has revolutionized cancer treatment and substantially improved patient
outcome with regard to multiple tumour types. However, most patients still do not benefit …
outcome with regard to multiple tumour types. However, most patients still do not benefit …
STING agonists as cancer therapeutics
A Amouzegar, M Chelvanambi, JN Filderman… - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
Cytoplasmic DNA: sources, sensing, and role in aging and disease
Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …
inflammation in diverse physiological and pathological contexts. Although the role of …
[HTML][HTML] DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity
Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency
(dMMR) are proposed as the major contributor to the high objective response rate in anti-PD …
(dMMR) are proposed as the major contributor to the high objective response rate in anti-PD …
Determinants of response and intrinsic resistance to PD-1 blockade in microsatellite instability–high gastric cancer
Sequence alterations in microsatellites and an elevated mutational burden are observed in
20% of gastric cancers and associated with clinical response to anti–PD-1 antibodies …
20% of gastric cancers and associated with clinical response to anti–PD-1 antibodies …
The complementarity of DDR, nucleic acids and anti-tumour immunity
Immune checkpoint blockade (ICB) immunotherapy is a first-line treatment for selected
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
cancers, yet the mechanisms of its efficacy remain incompletely understood. Furthermore …
Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response
J He, X Xiong, H Yang, D Li, X Liu, S Li, S Liao, S Chen… - Cell research, 2022 - nature.com
Personalized immunotherapy targeting tumor-specific antigens (TSAs) could generate
efficient and safe antitumor immune response without damaging normal tissues. Although …
efficient and safe antitumor immune response without damaging normal tissues. Although …