Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis of
tumor cells and their spread to various organs and tissues of body, providing undesirable …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Introduction Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation
where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus …

Abstract Epithelial-mesenchymal transition (EMT), a key step in the early stages of cancer
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …

Pancreatic cancer has one of the poorest prognoses of all malignancies, with little
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

Here we show that pemetrexed-treated mesothelioma cells undergo accelerated
senescence. This is characterized by the secretion of proinflammatory and mitogenic …

The neoplastic transformation of normal to metastatic cancer cells is a complex multistep
process involving the progressive accumulation of interacting genetic and epigenetic …

A significant amount of research indicates that the cyclooxygenase/prostaglandin E2 (PGE2)
pathway of inflammation contributes to the development and progression of a variety of …