The evolution and clinical impact of hepatitis B virus genome diversity

PA Revill, T Tu, HJ Netter, LKW Yuen… - Nature Reviews …, 2020 - nature.com
The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons
chronically infected, resulting in more than 880,000 deaths per year worldwide. HBV exists …

Hepatitis delta virus

SA Hughes, H Wedemeyer, PM Harrison - The Lancet, 2011 - thelancet.com
Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals
who have hepatitis B virus (HBV); worldwide more than 15 million people are co-infected …

Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update

SK Sarin, M Kumar, GK Lau, Z Abbas, HLY Chan… - Hepatology …, 2016 - Springer
Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest
rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection …

EASL Clinical Practice Guidelines on hepatitis delta virus

MR Brunetto, G Ricco, F Negro, H Wedemeyer… - Journal of …, 2023 - Elsevier
Hepatitis D virus (HDV) is a defective virus that requires the hepatitis B virus to complete its
life cycle and cause liver damage in humans. HDV is responsible for rare acute and chronic …

[HTML][HTML] EASL clinical practice guidelines: management of chronic hepatitis B virus infection

European Association For The Study Of The Liver - Journal of hepatology, 2012 - Elsevier
Our understanding of the natural history of hepatitis B virus (HBV) infection and the potential
for therapy of the resultant disease is continuously improving. New data have become …

[PDF][PDF] Late HDV RNA relapse after peginterferon alpha‐based therapy of chronic hepatitis delta

B Heidrich, C Yurdaydın, G Kabacam, BA Ratsch… - …, 2014 - Wiley Online Library
Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials
investigating the efficacy of pegylated interferon alpha (PEG‐IFNa) showed HDV RNA …

[HTML][HTML] A review on hepatitis D: From virology to new therapies

N Mentha, S Clément, F Negro, D Alfaiate - Journal of advanced research, 2019 - Elsevier
Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to
complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating …

Clinical features of hepatitis D

P Farci, GA Niro - Seminars in liver disease, 2012 - thieme-connect.com
Hepatitis D is caused by infection with hepatitis D virus (HDV), a defective RNA virus that
requires the obligatory helper function of hepatitis B virus (HBV) for its in vivo transmission …

[PDF][PDF] Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation

M Lütgehetmann, LV Mancke, T Volz, M Helbig… - …, 2012 - Wiley Online Library
No specific drugs are currently available against hepatitis delta virus (HDV), a defective virus
leading to the most severe form of chronic viral hepatitis in man. The lack of convenient HDV …

Hepatitis delta: virological and clinical aspects

LF Botelho-Souza, MPA Vasconcelos, AO Dos Santos… - Virology journal, 2017 - Springer
There are an estimated 400 million chronic carriers of HBV worldwide; between 15 and 20
million have serological evidence of exposure to HDV. Traditionally, regions with high rates …