Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …

Pyrazole moiety is considered as the most important therapeutic agent for the treatment of
inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant …

In the present investigation, synthesis of a series of extended conjugated δ-chloro-α-cyano
substituted indolyl chalcones (5a–p) was accomplished by reacting 3-cyanoacetylindole 2 …

Objective and design Carrageenan-induced paw edema has been described as a local and
acute inflammatory process. In fact, little is known about the time course and systemic …

A series of O-alkyl and O-acyl flavonoid derivatives was synthesized in high efficiency.
Alkylation and acylation of 5-hydroxyflavonoids showed that the low reactivity hydroxyl …

The search for novel drugs that can prevent or control Alzheimer's disease has attracted a lot
of attention from researchers across the globe. Phytochemicals are increasingly being used …

The therapeutic limitations and poor management of inflammatory conditions are anticipated
to impact patients negatively over the coming decades. Following the synthesis of the first …

A series of novel α, α-difluoro-β-hydroxyl pyrazole esters was prepared by Reformatsky
reaction. Subsequently, these esters were converted to acids and hydrazides. All the …

A new series of chalcones 4a-i; 6a, b, and 8 was synthesized from the condensation of
ketone 2, which was prepared from the reaction of thiourea derivative 1 with 3 …

This study reports the synthesis of two series of new purine bioisosteres comprising a
pyrazolo [3, 4‐d] pyrimidine scaffold linked to piperazine moiety through different amide …