Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

The ten-member SLC26 gene family encodes anion exchangers capable of transporting a
wide variety of monovalent and divalent anions. The physiological role (s) of individual …

Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed
anionic drugs. Here, we review the molecular properties of cloned transporters involved in …

A key function of the proximal tubule is retrieval of most of the vast quantities of NaCl and
water filtered by the kidney. Physiological studies using brush border vesicles and perfused …

Transepithelial Cl− and HCO3− transport is critically important for the function of all epithelia
and, when altered or ablated, leads to a number of diseases, including cystic fibrosis …

We report the molecular and functional characterization of murine Slc26a6, the putative
apical chloride-formate exchanger of the proximal tubule. The Slc26a6 transcript is …

Oxalate toxicity in LLC-PK 1 cells: Role of free radicals. Oxalate, the most common
constituent of kidney stones, is an end product of metabolism that is excreted by the kidney …

The fluid in the 14 distinct segments of the renal tubule undergoes sequential transport
processes that gradually convert the glomerular filtrate into the final urine. The solute carrier …

The solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate
specificity. Several members are ubiquitous while others show limited tissue distribution …