Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …

Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …

Multi-target directed ligands (MTDLs) have recently attracted significant interest due to their
exceptional effectiveness against multi-factorial Alzheimer's disease. The present work …

Monoamine oxidases (MAOs) are a family of flavin adenine dinucleotide-dependent
enzymes that catalyze the oxidative deamination of a wide range of endogenous and …

Chromone-2-carboxylate scaffold is growing as an important pharmacophore in medicinal
chemistry with diverse biological properties. We have developed a facile one-pot …

Isoflavones were synthesized via Suzuki–Miyaura coupling of 3-iodochromones and para-
methoxybenzene-and para-phenolboronic acid. In our hands, conditions commonly used for …

Here, we outline the synthesis of a few 2-methoxy-6-((4-(6-morpholinopyrimidin-4-yl)
piperazin-1-yl)(phenyl) methyl) phenol derivatives and assess their anti-inflammatory activity …

Benzopyrans (BZPs) are one of the most privileged and influential small O-heterocycles that
form the core of many natural compounds, commercial drugs, biological compositions …

Aryne insertion reaction with 2-aroyl malonates/cyanoesters lead to the formation of
diarylmethane or chromones depending on the substitution on the aryne ring. The presence …

Pyran-4-one and chromenone are well known bioactive compounds, particularly
antimicrobial activity. Present study investigation antibacterial activity of pyranone connected …