[HTML][HTML] Argonaute proteins confer immunity in all domains of life
PB Ugarte, P Barendse, DC Swarts - Current opinion in microbiology, 2023 - Elsevier
Both eukaryotes and prokaryotes (archaea and bacteria) encode an arsenal of immune
systems that protect the host against mobile genetic elements (MGEs) including viruses …
systems that protect the host against mobile genetic elements (MGEs) including viruses …
Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA
G Finocchio, B Koopal, A Potocnik… - Nucleic acids …, 2024 - academic.oup.com
In both prokaryotic and eukaryotic innate immune systems, TIR domains function as
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
Synechococcus elongatus Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids
The cyanobacterium Synechococcus elongatus PCC 7942 produces an active prokaryotic
Argonaute nuclease, SeAgo, whose function is unknown. Here, we show that SeAgo …
Argonaute nuclease, SeAgo, whose function is unknown. Here, we show that SeAgo …
Prokaryotic Argonaute nuclease cooperates with co-encoded RNase to acquire guide RNAs and target invader DNA
A Agapov, V Panteleev, E Kropocheva… - Nucleic Acids …, 2024 - academic.oup.com
Argonautes are an evolutionary conserved family of programmable nucleases that identify
target nucleic acids using small guide oligonucleotides. In contrast to eukaryotic Argonautes …
target nucleic acids using small guide oligonucleotides. In contrast to eukaryotic Argonautes …
Differential requirement for RecFOR pathway components in Thermus thermophilus
CL Gómez‐Campo, A Abdelmoteleb… - Environmental …, 2024 - Wiley Online Library
Recombinational repair is an important mechanism that allows DNA replication to overcome
damaged templates, so the DNA is duplicated timely and correctly. The RecFOR pathway is …
damaged templates, so the DNA is duplicated timely and correctly. The RecFOR pathway is …
Sensing of DNA modifications by pAgo proteins in vitro
M Beskrovnaia, A Agapov, K Makasheva, DO Zharkov… - Biochimie, 2024 - Elsevier
Many prokaryotic Argonaute (pAgo) proteins act as programmable nucleases that use small
guide DNAs for recognition and cleavage of complementary target DNA. Recent studies …
guide DNAs for recognition and cleavage of complementary target DNA. Recent studies …
Comparative structural insights and functional analysis for the distinct unbound states of Human AGO proteins
P Kakoulidis, E Theotoki, V Pantazopoulou, I Vlachos… - 2024 - researchsquare.com
The four human Argonaute (AGO) proteins, essential in RNA interference and gene
regulation, exhibit high sequence and structural similarity, yet differ functionally. Our …
regulation, exhibit high sequence and structural similarity, yet differ functionally. Our …
Structural and biochemical studies of an Argonaute and its associated protein from Archaeoglobus fulgidus
E Golovinas - 2024 - epublications.vu.lt
Abstract [eng] Argonaute (Ago) proteins, the key components of RNA interference (RNAi)
machinery, are ubiquitous across all domains of life. While eukaryotic Argonautes (eAgos) …
machinery, are ubiquitous across all domains of life. While eukaryotic Argonautes (eAgos) …