Peptide-drug conjugates and their targets in advanced cancer therapies

P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

N Gonzalez, TW Moody, H Igarashi, T Ito… - Current Opinion in …, 2008 - journals.lww.com
Bombesin-related peptides and their receptors: recent advanc... : Current Opinion in
Endocrinology, Diabetes and Obesity Bombesin-related peptides and their receptors: recent …

Gastrin-releasing peptide and cancer

O Patel, A Shulkes, GS Baldwin - … et Biophysica Acta (BBA)-Reviews on …, 2006 - Elsevier
Over the past 20 years, abundant evidence has been collected to suggest that gastrin-
releasing peptide (GRP) and its receptors play an important role in the development of a …

177Lu-AMBA: synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer

LE Lantry, E Cappelletti, ME Maddalena… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Gastrin-releasing peptide receptors (GRP-R) are upregulated in many cancers, including
prostate, breast, and lung. We describe a new radiolabeled bombesin (BBN) analog for …

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

P Moreno, I Ramos-Álvarez, TW Moody… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Despite remarkable advances in tumor treatment, many patients still die from
common tumors (breast, prostate, lung, CNS, colon, and pancreas), and thus, new …

18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer

X Zhang, W Cai, F Cao, E Schreibmann… - Journal of Nuclear …, 2006 - Soc Nuclear Med
The gastrin-releasing peptide receptor (GRPR) is found to be overexpressed in a variety of
human tumors. The aim of this study was to develop 18F-labeled bombesin analogs for PET …

Bombesin receptor-mediated imaging and cytotoxicity: review and current status

V Sancho, A Di Florio, TW Moody… - Current drug …, 2011 - ingentaconnect.com
The three mammalian bombesin (Bn) receptors (gastrin-releasing peptide [GRP] receptor,
neuromedin B [NMB] receptor, BRS-3) are one of the classes of G protein-coupled receptors …

Synthesis, 18F-Labeling, and in Vitro and in Vivo Studies of Bombesin Peptides Modified with Silicon-Based Building Blocks

A Höhne, L Mu, M Honer, PA Schubiger… - Bioconjugate …, 2008 - ACS Publications
The gastrin-releasing peptide receptor (GRPr) is overexpressed on various human tumors.
The goal of our study was the synthesis of new 18F-labeled bombesin analogues for the …

Insights into bombesin receptors and ligands: highlighting recent advances

I Ramos-Álvarez, P Moreno, SA Mantey, T Nakamura… - Peptides, 2015 - Elsevier
This following article is written for Prof. Abba Kastin's Festschrift, to add to the tribute to his
important role in the advancement of the role of peptides in physiological, as well as …

Radiolabelled peptides for oncological diagnosis

P Laverman, JK Sosabowski, OC Boerman… - European journal of …, 2012 - Springer
Radiolabelled receptor-binding peptides targeting receptors (over) expressed on tumour
cells are widely under investigation for tumour diagnosis and therapy. The concept of using …