Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Human biomonitoring (HBM) of dose and biochemical effect nowadays has tremendous
utility providing an efficient and cost effective means of measuring human exposure to …

DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-
position of guanine. Ever since identification of the first N7-guanine adduct, several hundred …

A genotoxin is a chemical or agent that can cause DNA or chromosomal damage. Such
damage in a germ cell has the potential to cause a heritable altered trait (germline mutation) …

Structural modifications of nucleobases within the deoxyribonucleic acid (DNA) of living cells
can be induced as a result of actions of specialized DNA-modifying enzymes (creating …

Exposure to endogenous and exogenous chemicals can lead to the formation of structurally
modified DNA bases (DNA adducts). If not repaired, these nucleobase lesions can cause …

Biomarker-driven drug selection plays a central role in cancer drug discovery and
development, and in diagnostic strategies to improve the use of traditional chemotherapeutic …

An electrochemical DNA biosensor was successfully fabricated by using (3-aminopropyl)
triethoxysilane (APTES) with zinc oxide (ZnO) nanorods synthesized using microwave …

Mass spectrometry has been widely utilised in the study of nucleobases, nucleosides and
nucleotides as components of nucleic acids and as bioactive metabolites in their own right …

Arrays suitable for genotoxicity screening are reported that generate metabolites from
cytochrome P450 enzymes (CYPs) in thin-film spots. Array spots containing DNA, various …