GFR decline as an end point for clinical trials in CKD: a scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration
The US Food and Drug Administration currently accepts halving of glomerular filtration rate
(GFR), assessed as doubling of serum creatinine level, as a surrogate end point for the …
(GFR), assessed as doubling of serum creatinine level, as a surrogate end point for the …
Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials
HJL Heerspink, T Greene, H Tighiouart… - The lancet Diabetes & …, 2019 - thelancet.com
Background Change in albuminuria has strong biological plausibility as a surrogate
endpoint for progression of chronic kidney disease, but empirical evidence to support its …
endpoint for progression of chronic kidney disease, but empirical evidence to support its …
GFR decline as an alternative end point to kidney failure in clinical trials: a meta-analysis of treatment effects from 37 randomized trials
Background There is increased interest in using alternative end points for trials of kidney
disease progression. The currently established end points of end-stage renal disease and …
disease progression. The currently established end points of end-stage renal disease and …
Early change in proteinuria as a surrogate end point for kidney disease progression: an individual patient meta-analysis
Background It is controversial whether proteinuria is a valid surrogate end point for
randomized trials in chronic kidney disease. Study Design Meta-analysis of individual …
randomized trials in chronic kidney disease. Study Design Meta-analysis of individual …
GFR decline and subsequent risk of established kidney outcomes: a meta-analysis of 37 randomized controlled trials
Background The currently established end points for clinical trials of progression of chronic
kidney disease (CKD) are end-stage renal disease and doubling of serum creatinine level …
kidney disease (CKD) are end-stage renal disease and doubling of serum creatinine level …
Podocyte injury: the role of proteinuria, urinary plasminogen, and oxidative stress
L Raij, R Tian, JS Wong, JC He… - American Journal of …, 2016 - journals.physiology.org
Podocytes are the key target for injury in proteinuric glomerular diseases that result in
podocyte loss, progressive focal segmental glomerular sclerosis (FSGS), and renal failure …
podocyte loss, progressive focal segmental glomerular sclerosis (FSGS), and renal failure …
Utility and validity of estimated GFR–based surrogate time-to-event end points in CKD: a simulation study
Background There is interest in surrogate end points for clinical trials of chronic kidney
disease progression because currently established end points—end-stage renal disease …
disease progression because currently established end points—end-stage renal disease …
[HTML][HTML] The IgA1 immune complex–mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA …
H Tamouza, JM Chemouny, LR Kafkova, L Berthelot… - Kidney international, 2012 - Elsevier
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has
significant morbidity and mortality as 20–40% of patients progress to end-stage renal …
significant morbidity and mortality as 20–40% of patients progress to end-stage renal …
Reduction of albumin urinary excretion is associated with reduced cardiovascular events in hypertensive and/or diabetic patients. A meta-regression analysis of 32 …
G Savarese, A Dei Cas, G Rosano, C D'Amore… - International journal of …, 2014 - Elsevier
Background The association between renal dysfunction and risk of cardiovascular (CV)
events and mortality has been reported in several studies. However, it is unclear whether …
events and mortality has been reported in several studies. However, it is unclear whether …
[HTML][HTML] A systematic review comparing the evidence for kidney function outcomes between oral antidiabetic drugs for type 2 diabetes
SV Wilkinson, LA Tomlinson, M Iwagami… - Wellcome open …, 2018 - ncbi.nlm.nih.gov
Background: The development of kidney disease is a serious complication among people
with type 2 diabetes mellitus, associated with substantially increased morbidity and mortality …
with type 2 diabetes mellitus, associated with substantially increased morbidity and mortality …