Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
Immunology of human fibrosis
M Bhattacharya, P Ramachandran - Nature Immunology, 2023 - nature.com
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
S Alivernini, L MacDonald, A Elmesmari, S Finlay… - Nature medicine, 2020 - nature.com
Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …
Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the
most widespread arthritis in the world, using the powerful tool of single-cell RNA …
most widespread arthritis in the world, using the powerful tool of single-cell RNA …
Reproducing human and cross-species drug toxicities using a Liver-Chip
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …
drugs may produce discordant results or fail to predict complications in humans, contributing …
Hepatic macrophages: Key players in the development and progression of liver fibrosis
D Cheng, J Chai, H Wang, L Fu, S Peng… - Liver …, 2021 - Wiley Online Library
Hepatic fibrosis is a common pathological process involving persistent liver injury with
various etiologies and subsequent inflammatory responses that occur in chronic liver …
various etiologies and subsequent inflammatory responses that occur in chronic liver …
Efferocytosis and its role in inflammatory disorders
Y Ge, M Huang, Y Yao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Efferocytosis is the effective clearance of apoptotic cells by professional and non-
professional phagocytes. The process is mechanically different from other forms of …
professional phagocytes. The process is mechanically different from other forms of …
The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease
The pathogenesis of diabetic kidney disease (DKD) involves multifactorial processes that
converge to initiate and advance the disease. Although DKD is not typically classified as an …
converge to initiate and advance the disease. Although DKD is not typically classified as an …
A growth factor–expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15
A Patsalos, L Halasz, MA Medina-Serpas… - Journal of Experimental …, 2021 - rupress.org
Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
G Locatelli, D Theodorou, A Kendirli, MJC Jordao… - Nature …, 2018 - nature.com
Mononuclear phagocytes are key regulators of both tissue damage and repair in
neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte …
neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte …