“Organic synthesis” is a compound-creating activity often focused on biologically active
small molecules. This special issue of PNAS explores innovations and trends in the field that …

A long-standing controversy is whether autophagy is a bona fide cause of mammalian cell
death. We used a cell-penetrating autophagy-inducing peptide, Tat-Beclin 1, derived from …

Cytotoxic compounds are important drugs and research tools. Here, we introduce a method,
scalable time-lapse analysis of cell death kinetics (STACK), to quantify the kinetics of …

As both the amount of generated biological data and the processing compute power
increase, computational experimentation is no longer the exclusivity of bioinformaticians, but …

Autophagy is an evolutionarily conserved catabolic process that directs cytoplasmic
proteins, organelles and microbes to lysosomes for degradation. Autophagy acts at the …

Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway
in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for …

Over the past decade, tremendous progress in high-throughput small molecule-screening
methods has facilitated the rapid expansion of phenotype-based data. Parallel advances in …

Compounds and compositions for reducing intracellular lipid accumulation in a cell are
described herein. These com pounds are useful for the treatment and prevention of …

The central concept underlying precision medicine is a mechanistic understanding of each
disease and its response to therapy sufficient to direct a specific intervention. To execute on …

Studies of the genetics of cardiovascular disease and its risk factors have identified many
chromosomal loci that contribute to cardiovascular traits. When combining the outcomes of …