T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …

Bispecific molecules redirecting the cytotoxicity of T-cells are a growing class of therapeutics
with numerous molecules being tested in clinical trials. However, it has been a long way …

Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited
functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

Antigen recognition by the T-cell receptor (TCR) is a hallmark of the adaptive immune
system. When the TCR engages a peptide bound to the restricting major histocompatibility …

Cholesterol molecules specifically bind to the resting αβTCR to inhibit cytoplasmic CD3ζ
ITAM phosphorylation through sequestering the TCR-CD3 complex in an inactive …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …

Ag-specific T cell tolerance plays a critical role in tumor escape. Recent studies implicated
myeloid-derived suppressor cells (MDSCs) in the induction of CD8+ T cell tolerance in tumor …

T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in
the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs …

Signaling through the T cell receptor (TCR) controls adaptive immune responses. Antigen
binding to TCRαβ transmits signals through the plasma membrane to induce …