Tendon and ligament healing and current approaches to tendon and ligament regeneration

NL Leong, JL Kator, TL Clemens… - Journal of …, 2020 - Wiley Online Library
Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …

Practical considerations for translating mesenchymal stromal cell-derived extracellular vesicles from bench to bed

PPY Lui, YT Leung - Pharmaceutics, 2022 - mdpi.com
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have shown
potential for the treatment of tendon and ligament injuries. This approach can eliminate the …

Treatment of lateral epicondylosis by using allogeneic adipose-derived mesenchymal stem cells: a pilot study

SY Lee, W Kim, C Lim, SG Chung - Stem Cells, 2015 - academic.oup.com
Mesenchymal stem cell therapy is a novel regenerative approach for treating tendinopathy.
Here, we evaluated the safety and efficacy of allogeneic adipose-derived mesenchymal …

Human mesenchymal stem cells modulate inflammatory cytokines after spinal cord injury in rat

L Machová Urdzíková, J Růžička, M LaBagnara… - International journal of …, 2014 - mdpi.com
Transplantation of mesenchymal stem cells (MSC) improves functional recovery in
experimental models of spinal cord injury (SCI); however, the mechanisms underlying this …

[HTML][HTML] Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing

M Schneider, P Angele, TAH Järvinen… - Advanced drug delivery …, 2018 - Elsevier
Due to the increasing age of our society and a rise in engagement of young people in
extreme and/or competitive sports, both tendinopathies and tendon ruptures present a …

Mitochondrial transfer from bone mesenchymal stem cells protects against tendinopathy both in vitro and in vivo

B Wei, M Ji, Y Lin, S Wang, Y Liu, R Geng, X Hu… - Stem Cell Research & …, 2023 - Springer
Background Although mesenchymal stem cells (MSCs) have been effective in tendinopathy,
the mechanisms by which MSCs promote tendon healing have not been fully elucidated. In …

Electrospun PLGA fiber diameter and alignment of tendon biomimetic fleece potentiate tenogenic differentiation and immunomodulatory function of amniotic epithelial …

M El Khatib, A Mauro, M Di Mattia, R Wyrwa… - Cells, 2020 - mdpi.com
Injured tendons are challenging in their regeneration; thus, tissue engineering represents a
promising solution. This research tests the hypothesis that the response of amniotic …

Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration

X Ren, H Zhuang, Y Zhang, P Zhou - Journal of Nanobiotechnology, 2023 - Springer
Background Tendon injuries have a high incidence and limited treatment options. Stem cell
transplantation is essential for several medical conditions like tendon injuries. However …

The roles and therapeutic potentialof mesenchymal stem/stromal cells and their extracellular vesicles in tendinopathies

D Quintero, C Perucca Orfei, LD Kaplan… - … in Bioengineering and …, 2023 - frontiersin.org
Tendinopathies encompass a highly prevalent, multi-faceted spectrum of disorders,
characterized by activity-related pain, compromised function, and propensity for an extended …

SM04755, a small‐molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy

V Deshmukh, T Seo, AL O'Green… - Journal of …, 2021 - Wiley Online Library
The Wnt pathway is upregulated in tendinopathy, affecting inflammation and tenocyte
differentiation. Given its potential role in tendinopathy, this signaling pathway may be a …