Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery
SX Phua, KF Chan, CTT Su, JJ Poh… - Bioscience …, 2019 - portlandpress.com
The reductionist approach is prevalent in biomedical science. However, increasing evidence
now shows that biological systems cannot be simply considered as the sum of its parts. With …
now shows that biological systems cannot be simply considered as the sum of its parts. With …
[HTML][HTML] Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L
Interest in IgA as an alternative antibody format has increased over the years with much
remaining to be investigated in relation to interactions with immune cells. Considering the …
remaining to be investigated in relation to interactions with immune cells. Considering the …
[HTML][HTML] To plate or to simply unfreeze, that is the question for optimal plasmid extraction
RKR Thean, DXY Ong, ZSL Heng… - Journal of …, 2021 - ncbi.nlm.nih.gov
Many molecular biology applications require fast plasmid DNA extraction, spurring multiple
studies on how to speed up the process. It is regularly instructed in standard laboratory …
studies on how to speed up the process. It is regularly instructed in standard laboratory …
[HTML][HTML] The synergistic effects of the constant region and variable heavy chain families of multimeric immunoglobulin M on its interaction with Fc-mu receptor and …
Aim: As the primary response antibody with increasing use as a therapeutic immunoglobulin
(Ig) format, IgM is also the largest antibody structure among the five major human isotypes …
(Ig) format, IgM is also the largest antibody structure among the five major human isotypes …
The synergistic effects of the VH families and CH regions of multimeric IgM on its interaction with FcμR, and antigen
As the primary response antibody with increasing interest as a therapeutic antibody format,
IgM is also the largest antibody structure among the five major human isotypes …
IgM is also the largest antibody structure among the five major human isotypes …
Role of FcαR EC2 region in extracellular membrane localization
SX Phua, WH Lua, SKE Gan - Cell Cycle, 2018 - Taylor & Francis
The FcαR receptor (CD89) binds to the constant region of Immunoglobulin (Ig) A to mediate
mucosal immunity [1–2]. FcαR consist of five exons: two that code for the signal peptide …
mucosal immunity [1–2]. FcαR consist of five exons: two that code for the signal peptide …
Engaging the 'A'Class Antibody: Variable-Heavy (VH) region influencing IgA1&2 engagement of FcαRI and superantigen proteins G, A, and L
Interest in IgA as an alternative therapeutic and diagnostic antibody has increased over the
years, yet much remains to be investigated especially given their importance in activating …
years, yet much remains to be investigated especially given their importance in activating …
[PDF][PDF] APD Trove Journal–scope, aims, and purpose
SKE Gan - oar.a-star.edu.sg
BACKGROUND “Publish or perish” is a mantra that is familiar to all involved in academia.
With their careers on the line, publications have become a crucial outlet that most academics …
With their careers on the line, publications have become a crucial outlet that most academics …