Frailty can be viewed as a state of physiological decline that increases susceptibility to
adverse health outcomes. This loss of physiological reserve means that even small stressors …

Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …

The impact of COVID-19 on the elderly is devastating, and nursing homes are struggling to
provide the best care to the most fragile. The urgency and severity of the pandemic forces …

Frailty is a complex syndrome affecting a growing sector of the global population as medical
developments have advanced human mortality rates across the world. Our current …

Global average life expectancy continues to rise. As aging increases the likelihood of frailty,
which encompasses metabolic, musculoskeletal, and cognitive deficits, there is a need for …

Pre-clinical research in aging is hampered by the scarcity of studies modeling its
heterogeneity and complexity forged by pathophysiological conditions throughout the life …

Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites,
which can accurately measure chronological age in different species. Recently, several …

In addition to cognitive decline, patients with Alzheimer's disease (AD) exhibit sensory,
motor, and neuropsychiatric deficits. Many AD patients also show weight loss, suggesting …

New evidence refers to a high degree of heterogeneity in normal but also Alzheimer's
disease (AD) clinical and temporal patterns, increased mortality, and the need to find …

Many age-related biochemical, physiological and behavioral changes are known to be sex-
specific. However, how sex influences frailty status and mortality risk in frail rodents has yet …