Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: underlying mechanisms based on cell and molecular targets

W Li, L Yu, W Li, G Ge, Y Ma, L Xiao, Y Qiao… - Ageing Research …, 2023 - Elsevier
Inflammatory arthritis, primarily including rheumatoid arthritis, osteoarthritis and ankylosing
spondylitis, is a group of chronic inflammatory diseases, whose general feature is joint …

Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence

P Zhang, K Li, A Kamali, R Ziadlou, P Ahmad… - Arthritis research & …, 2022 - Springer
Osteoarthritis (OA) is one of the most common musculoskeletal degenerative diseases and
contributes to heavy socioeconomic burden. Current pharmacological and conventional non …

Recent advances in small molecule inhibitors for the treatment of osteoarthritis

J Lin, S Jia, W Zhang, M Nian, P Liu, L Yang… - Journal of Clinical …, 2023 - mdpi.com
Osteoarthritis refers to a degenerative disease with joint pain as the main symptom, and it is
caused by various factors, including fibrosis, chapping, ulcers, and loss of articular cartilage …

Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation

ZL Zou, MH Sun, WF Yin, L Yang, LY Kong - Phytomedicine, 2021 - Elsevier
Background Osteoarthritis (OA) is an intractable degenerative disease of the whole joint,
which is characterized by synovitis inflammation, cartilage damage, and chronic pain. Tumor …

Anti-inflammatory and chondroprotective effects of vanillic acid and epimedin C in human osteoarthritic chondrocytes

R Ziadlou, A Barbero, I Martin, X Wang, L Qin, M Alini… - Biomolecules, 2020 - mdpi.com
In osteoarthritis (OA), inhibition of excessively expressed pro-inflammatory cytokines in the
OA joint and increasing the anabolism for cartilage regeneration are necessary. In this ex …

The Therapeutic Effects of Treadmill Exercise on Osteoarthritis in Rats by Inhibiting the HDAC3/NF-KappaB Pathway in vivo and in vitro

H Zhang, L Ji, Y Yang, Y Wei, X Zhang, Y Gang… - Frontiers in …, 2019 - frontiersin.org
Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone
deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the …

[HTML][HTML] Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study

H Guo, W Yin, Z Zou, C Zhang, M Sun, L Min… - Journal of advanced …, 2021 - Elsevier
Introduction: Disruptions of extracellular matrix (ECM) degradation homeostasis play a
significant role in the pathogenesis of osteoarthritis (OA). Matrix metalloproteinase 13 …

Urolithin A attenuates RANKL-induced osteoclastogenesis by co-regulating the p38 MAPK and Nrf2 signaling pathway

W Wei, C Peng, R Gu, X Yan, J Ye, Z Xu… - European Journal of …, 2022 - Elsevier
As a critical regulator of bone resorption. osteoclastogenesis is closely associated with
osteoporosis (OP) and commonly induced by receptor activator of nuclear factor-κB ligand …

miR‐3960 from Mesenchymal Stem Cell‐Derived Extracellular Vesicles Inactivates SDC1/Wnt/β‐Catenin Axis to Relieve Chondrocyte Injury in Osteoarthritis by …

P Ye, Z Mi, D Wei, P Gao, M Ma… - Stem cells …, 2022 - Wiley Online Library
Osteoarthritis (OA) is a serious disease of the articular cartilage characterized by excessive
inflammation. Lately, mesenchymal stem cell‐(MSC‐) derived extracellular vesicles (EVs) …

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

X Li, S Zhang - Chinese medicine, 2020 - Springer
Osteoarthritis (OA) is a common chronic articular degenerative disease, and characterized
by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone …