Down‐regulation of intracellular anti‐apoptotic proteins, particularly c‐FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL

A Hassanzadeh, M Farshdousti Hagh… - Journal of cellular …, 2018 - Wiley Online Library
Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL or Apo2L) is a member of
the tumor necrosis factor (TNF) superfamily that induces apoptosis in different types of …

[HTML][HTML] The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter

KH Wu, CT Ho, ZF Chen, LC Chen… - journal of food and drug …, 2018 - Elsevier
Human triple-negative breast cancer (TNBC) is the most aggressive and poorly understood
subclass of breast cancer. Glucose transporters (GLUTs) are required for glucose uptake in …

Apple polyphenol phloretin inhibits colorectal cancer cell growth via inhibition of the type 2 glucose transporter and activation of p53-mediated signaling

ST Lin, SH Tu, PS Yang, SP Hsu, WH Lee… - Journal of agricultural …, 2016 - ACS Publications
Glucose transporters (GLUTs) are required for glucose uptake in malignant cells, and they
can be used as molecular targets for cancer therapy. An RT-PCR analysis was performed to …

[HTML][HTML] Chrysin and Capsaicin induces premature senescence and apoptosis via mitochondrial dysfunction and p53 elevation in Cervical cancer cells

JS Pawar, S Mustafa, I Ghosh - Saudi journal of biological sciences, 2022 - Elsevier
Current studies are focusing on the anti-cancerous properties of natural bioactive
compounds, primarily those included in the human diet. These compounds have the …

Targeting mitochondrial therapy in the regulation of HPV infection and HPV-related cancers

A Cruz-Gregorio, AK Aranda-Rivera, GN Roviello… - Pathogens, 2023 - mdpi.com
It has been previously proposed that some types of cancer cells reprogram their metabolic
pathways, favoring the metabolism of glucose by aerobic glycolysis (Warburg effect) instead …

Fucoidan induces ROS-dependent epigenetic modulation in cervical cancer HeLa cell

S Mustafa, JS Pawar, I Ghosh - International Journal of Biological …, 2021 - Elsevier
Fucoidan is a sulfated polysaccharide obtained from marine algae and known for various
pharmacological activities. In this study, we investigated the effect of Fucoidan on cell …

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification

S Melnik, D Dvornikov, K Müller-Decker, S Depner… - Cell discovery, 2018 - nature.com
Use of the diabetes type II drug Metformin is associated with a moderately lowered risk of
cancer incidence in numerous tumor entities. Studying the molecular changes associated …

Rotenone restrains colon cancer cell viability, motility and epithelial‑mesenchymal transition and tumorigenesis in nude mice via the PI3K/AKT pathway

W Xiao, Y Liu, M Dai, Y Li… - International …, 2020 - spandidos-publications.com
Rotenone, a natural hydrophobic pesticide, has been reported to display anticancer activity
in a variety of cancer cells. However, the mechanism of rotenone on colon cancer (CC) cell …

Hypoglycemia enhances epithelial‐mesenchymal transition and invasiveness, and restrains the warburg phenotype, in hypoxic HeLa cell cultures and microspheroids

Á Marín‐Hernández, JC Gallardo‐Pérez… - Journal of Cellular …, 2017 - Wiley Online Library
The accelerated growth of solid tumors leads to episodes of both hypoxia and hypoglycemia
(HH) affecting their intermediary metabolism, signal transduction, and transcriptional activity …

JNJ-64619178 radiosensitizes and suppresses fractionated ionizing radiation-induced neuroendocrine differentiation (NED) in prostate cancer

JS Pawar, MY Al-Amin, CD Hu - Frontiers in Oncology, 2023 - frontiersin.org
Background Radiation therapy (RT) is a standard treatment regimen for locally advanced
prostate cancer; however, its failure results in tumor recurrence, metastasis, and cancer …