An updated overview of diabetic nephropathy: Diagnosis, prognosis, treatment goals and latest guidelines

NM Selby, MW Taal - Diabetes, Obesity and Metabolism, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is a major healthcare challenge. It occurs in up to 50% of those
living with diabetes, is a major cause of end‐stage kidney disease (ESKD) that requires …

Glomerular hyperfiltration

M Cortinovis, N Perico, P Ruggenenti… - Nature reviews …, 2022 - nature.com
Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment

L Tonneijck, MHA Muskiet, MM Smits… - Journal of the …, 2017 - journals.lww.com
An absolute, supraphysiologic elevation in GFR is observed early in the natural history in
10%–67% and 6%–73% of patients with type 1 and type 2 diabetes, respectively. Moreover …

Estimated GFR: time for a critical appraisal

E Porrini, P Ruggenenti, S Luis-Lima… - Nature Reviews …, 2019 - nature.com
Since 1957, over 70 equations based on creatinine and/or cystatin C levels have been
developed to estimate glomerular filtration rate (GFR). However, whether these equations …

Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind …

AH Barnett, A Mithal, J Manassie, R Jones… - The lancet Diabetes & …, 2014 - thelancet.com
Background Diabetes is a leading cause of chronic kidney disease (CKD) worldwide.
Optimum glycaemic control in patients with type 2 diabetes is important to minimise the risk …

Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease

APJ De Vries, P Ruggenenti, XZ Ruan… - The lancet Diabetes & …, 2014 - thelancet.com
The global increase in chronic kidney disease (CKD) parallels the obesity epidemic. Obesity
conveys a gradual but independent risk of progression of CKD that seems irrespective of the …

Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with …

P Delanaye, N Ebert, T Melsom, F Gaspari… - Clinical kidney …, 2016 - academic.oup.com
While there is general agreement on the necessity to measure glomerular filtration rate
(GFR) in many clinical situations, there is less agreement on the best method to achieve this …

Non-proteinuric pathways in loss of renal function in patients with type 2 diabetes

E Porrini, P Ruggenenti, CE Mogensen… - The lancet Diabetes & …, 2015 - thelancet.com
Largely on the basis of data from patients with type 1 diabetes, the natural history of diabetic
renal disease has been classified as a sequence of three stages: normoalbuminuria …

Clinical predictive factors in diabetic kidney disease progression

NJ Radcliffe, J Seah, M Clarke… - Journal of diabetes …, 2017 - Wiley Online Library
Diabetic kidney disease (DKD) represents a major component of the health burden
associated with type 1 and type 2 diabetes. Recent advances have produced an explosion …

Glomerular hyperfiltration predicts kidney function decline and mortality in type 1 and type 2 diabetes: a 21-year longitudinal study

D Moriconi, L Sacchetta, M Chiriacò, L Nesti… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE To evaluate the prognostic value of glomerular hyperfiltration on long-term
kidney-related outcomes and mortality in patients with diabetes. RESEARCH DESIGN AND …