Highlights•Mathematical models as tools to establish quantitative links between bioprocess
CPPs and KPIs.•Review of the advantages and limitations of mechanistic and statistical …

Abstract Industrial Internet of Things (IIoT) is a system of interconnected devices that, via the
use of various technologies, such as soft sensors, cloud computing, data analytics, machine …

The central relevance of cellular heterogeneity to biological phenomena raises the rational
needs for analytical techniques with single-cell resolution. Here, we developed a single-cell …

Mesenchymal stem cells (MSCs) are proliferative and multipotent cells that play a key role in
the bone regeneration process. Empirical data have repeatedly shown the bioregulatory …

The therapeutic use of mesenchymal stem cells (MSCs) becomes more and more important
due to their potential for cell replacement procedures as well as due to their …

Demand for mesenchymal stem cell (MSC)-based therapies for various clinical applications
has been steadily increasing. Suitable implants can be obtained by in-vitro osteogenic …

Agent-based modeling (ABM) is a powerful approach for studying complex systems and
their underlying properties by explicitly modeling the actions and interactions of individual …

Περίληψη Η κλινική ανάγκη για οστικά εμφυτεύματα αυξάνεται σταθερά τις τελευταίες
δεκαετίες. Η αυξανόμενη αυτή ζήτηση αποδίδεται εν μέρει στην άνοδο του βιοτικού επιπέδου …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease. Symptoms can be
characterised by the inflammation of the synovium and irreversible articular bone erosion …