Nicotinic ACh receptors as therapeutic targets in CNS disorders

KT Dineley, AA Pandya, JL Yakel - Trends in pharmacological sciences, 2015 - cell.com
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

The cholinergic system in aging and neuronal degeneration

R Schliebs, T Arendt - Behavioural brain research, 2011 - Elsevier
The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

[HTML][HTML] Mammalian nicotinic acetylcholine receptors: from structure to function

EX Albuquerque, EFR Pereira… - Physiological …, 2009 - journals.physiology.org
The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Structural and functional diversity of native brain neuronal nicotinic receptors

C Gotti, F Clementi, A Fornari, A Gaimarri… - Biochemical …, 2009 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion
channels present in the central and peripheral nervous systems, that are permeable to mono …

[HTML][HTML] Nicotinic acetylcholine receptors in neurological and psychiatric diseases

AV Terry Jr, K Jones, D Bertrand - Pharmacological Research, 2023 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy

DG Wilkinson, PT Francis, E Schwam, J Payne-Parrish - Drugs & aging, 2004 - Springer
The deficiency in cholinergic neurotransmission in Alzheimer's disease has led to the
development of cholinesterase inhibitors as the first-line treatment for symptoms of this …

Galantamine—a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease

S Lilienfeld - CNS drug reviews, 2002 - Wiley Online Library
Galantamine hydrobromide is a tertiary alkaloid drug that has been developed and
approved in a number of countries including the USA and several countries in Europe as a …

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors

C Heeschen, M Weis, A Aicher… - The Journal of …, 2002 - Am Soc Clin Investig
We have recently reported that nicotine has angiogenic effects, which appear to be
mediated through non-neuronal nicotinic acetylcholine receptors (nAChRs). Here, we …

Nicotinic receptor subtypes and cognitive function

ED Levin - Journal of neurobiology, 2002 - Wiley Online Library
Nicotinic receptor systems are involved in a wide variety of behavioral functions including
cognitive function. Nicotinic medications may provide beneficial treatment for cognitive …