Recent advances in the design and sensing applications of hemin/coordination polymer‐based nanocomposites

AM Alsharabasy, A Pandit, P Farràs - Advanced Materials, 2021 - Wiley Online Library
The fabrication of biomimetic catalysts as substituents for enzymes is of critical interest in the
field due to the problems associated with the extraction, purification, and storage of enzymes …

Haemozoin formation

TJ Egan - Molecular and biochemical parasitology, 2008 - Elsevier
Formation of malaria pigment or haemozoin is the major route of haem detoxification in the
malaria parasite Plasmodium falciparum as well as several other species of …

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

M Chugh, V Sundararaman, S Kumar… - Proceedings of the …, 2013 - National Acad Sciences
Malaria parasites use hemoglobin (Hb) as a major nutrient source in the intraerythrocytic
stage, during which heme is converted to hemozoin (Hz). The formation of Hz is essential for …

Schistosomiasis chemotherapy

SAL Thétiot‐Laurent, J Boissier… - Angewandte Chemie …, 2013 - Wiley Online Library
After malaria, schistosomiasis (or bilharzia) is the second most prevalent disease in Africa,
and is occurring in over 70 countries in tropical and subtropical regions. It is estimated that …

Interplay between malaria, crystalline hemozoin formation, and antimalarial drug action and design

I Weissbuch, L Leiserowitz - Chemical reviews, 2008 - ACS Publications
This review on the interplay between malaria, antimalarial drugs, and hemozoin crystals is
directed, on one hand, to biologists and pharmaceutical chemists who wish to have a …

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

TJ Egan - Journal of inorganic biochemistry, 2008 - Elsevier
The recent literature on hemozoin/β-hematin formation is reviewed, with an emphasis on the
mechanism of its formation. Recent findings from unrelated organisms that produce …

Schistosome feeding and regurgitation

PJ Skelly, AA Da'dara, XH Li, W Castro-Borges… - PLoS …, 2014 - journals.plos.org
Schistosomes are parasitic flatworms that infect> 200 million people worldwide, causing the
chronic, debilitating disease schistosomiasis. Unusual among parasitic helminths, the long …

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization

JM Pisciotta, I Coppens, AK Tripathi… - Biochemical …, 2007 - portlandpress.com
The intraerythrocytic malaria parasite constructs an intracellular haem crystal, called
haemozoin, within an acidic digestive vacuole where haemoglobin is degraded. Haem …

Lipids in host–pathogen interactions: pathogens exploit the complexity of the host cell lipidome

YPM van der Meer-Janssen, J van Galen… - Progress in lipid …, 2010 - Elsevier
Lipids were long believed to have a structural role in biomembranes and a role in energy
storage utilizing cellular lipid droplets and plasma lipoproteins. Research over the last …

Malaria pigment crystals: The achilles′ heel of the malaria parasite

S Kapishnikov, E Hempelmann, M Elbaum… - …, 2021 - Wiley Online Library
The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the
malaria parasite, is reviewed as an antimalarial drug target. We first focus on the in‐vivo …