Chemical modification of aptamers for increased binding affinity in diagnostic applications: Current status and future prospects

JP Elskens, JM Elskens, A Madder - International journal of molecular …, 2020 - mdpi.com
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …

Improving aptamer performance: key factors and strategies

H Yu, J Zhu, G Shen, Y Deng, X Geng, L Wang - Microchimica Acta, 2023 - Springer
Aptamers are functional single-stranded oligonucleotide fragments isolated from
randomized libraries by Systematic Evolution of Ligands by Exponential Enrichment …

Aptameric biosensor for the sensitive detection of major shrimp allergen, tropomyosin

R Chinnappan, AA Rahamn, R AlZabn, S Kamath… - Food Chemistry, 2020 - Elsevier
The development of a sensitive and rapid detection approach for allergens in various food
matrices is essential to assist patients in managing their allergies. The most common …

Recent progress in micro/nano biosensors for shellfish toxin detection

Y Tian, L Du, P Zhu, Y Chen, W Chen, C Wu… - Biosensors and …, 2021 - Elsevier
Shellfish toxins, as one kind of marine toxin, have attracted worldwide attention due to their
severe threat to food safety and human health. Therefore, it is highly essential and urgent to …

Emerging roles of the aptasensors as superior bioaffinity sensors for monitoring shellfish toxins in marine food chain

Y Zhao, L Li, X Yan, L Wang, R Ma, X Qi… - Journal of Hazardous …, 2022 - Elsevier
Shellfish toxins are derived from harmful algae and are easily accumulated in environment
and marine food through the food chain, exposing high risks on human health. Preliminary …

Single-stranded DNA binding protein coupled aptasensor with carbon-gold nanoparticle amplification for marine toxins detection assisted by a miniaturized …

L Kong, Y Gan, T Wang, X Sun, C Ma, X Wang… - Journal of Hazardous …, 2023 - Elsevier
Okadaic acid (OA), one of the most widely distributed marine toxins worldwide poses a
severe threat to human health. Previous sensing methods for OA detection are usually …

Graphene oxide-based fluorescent biosensors for pathogenic bacteria detection: A review

S Liu, F Lu, S Chen, Y Ning - Analytica Chimica Acta, 2024 - Elsevier
Background Pathogenic bacteria are widespread in nature and can cause infections and
various complications, thereby posing a severe risk to public health. Therefore, simple …

Aptamer-based microcantilever-array biosensor for ultra-sensitive and rapid detection of okadaic acid

Y Wang, D Rao, X Wu, Q Zhang, S Wu - Microchemical Journal, 2021 - Elsevier
Okadaic acid (OA) is widely present in seafood and consuming OA contaminated seafood
can cause carcinogenic or teratogenic effects. Therefore, developing ultra-sensitive and …

Discovery and optimization of an aptamer and its sensing ability to amantadine based on SERS via binary metal nanoparticles

N Duan, K Ren, C Lyu, Z Wang… - Journal of Agricultural and …, 2022 - ACS Publications
With the growing concern of illegal abuse of amantadine (AMD) and its potential harmful
impact on humans, detection of AMD has become an urgent food safety and environmental …

Truncated affinity-improved aptamer for selective and sensitive detection of streptomycin in dairy products with label-free electrochemical aptasensor

Y Hui, D Yang, W Wang, Y Liu, C He, B Wang - Journal of Food …, 2023 - Elsevier
The overuse of streptomycin (STR) can result in their residues in food, posing serious side
effects on human health. This work aims to develop a novel and accurate electrochemical …