The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

Chronic T rypanosoma cruzi infections lead to cardiomyopathy in 20–30% of cases. A
causal link between cardiac infection and pathology has been difficult to establish because …

Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …

We herein developed a reductive transamidation reaction between N-acyl benzotriazoles
(AcBt) and organic nitro compounds or NaNO2 under mild conditions. This protocol …

Abstract Machine learning and deep learning approaches have been increasingly used in
the field of toxicology through prediction models developed using various toxicity data …

The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the
world's major neglected infections. Although development of improved antiparasitic drugs is …

CYP51 is considered one of the most ancient P450 protein families. 1 It is perhaps the only
P450 protein family whose members are spread across all biological kingdoms, although it …

An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma
cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease …

In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but
nonsterilising immune responses. Infected cells are difficult to detect because they are …