Metal ion-based RNA cleavage as a structural probe

M Forconi, D Herschlag - Methods in enzymology, 2009 - Elsevier
It is well established that many metal ions accelerate the spontaneous degradation of RNA.
This property has been exploited in several ways to garner information about RNA structure …

Flavonolate Complexes of MII (M = Mn, Fe, Co, Ni, Cu, and Zn). Structural and Functional Models for the ES (Enzyme–Substrate) Complex of Quercetin 2,3 …

YJ Sun, QQ Huang, T Tano, S Itoh - Inorganic Chemistry, 2013 - ACS Publications
A series of flavonolate complexes [MIIL (fla)](M= Mn (1), Fe (2), Co (3), Ni (4), Cu (5), and Zn
(6), LH: 2-{[bis (pyridin-2-ylmethyl) amino] methyl} benzoic acid, fla: flavonolate) have been …

[PDF][PDF] Thermodynamic determination of RNA duplex stability in magnesium solutions

SJ Arteaga, MS Adams, NL Meyer, KE Richardson… - Biophysical …, 2023 - cell.com
The prediction of RNA secondary structure and thermodynamics from sequence relies on
free energy minimization and nearest neighbor parameters. Currently, algorithms used to …

NMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights into RNA–Metal-Ion Interactions

E Bonneau, P Legault - Biochemistry, 2014 - ACS Publications
Metal cations represent key elements of RNA structure and function. In the Neurospora VS
ribozyme, metal cations play diverse roles; they are important for substrate recognition …

Simulations predict preferred Mg2+ coordination in a nonenzymatic primer extension reaction center

S Mittal, C Nisler, JW Szostak - bioRxiv, 2023 - biorxiv.org
The mechanism by which genetic information was copied prior to the evolution of ribozymes
is of great interest because of its importance to the origin of life. The most effective known …

On the role of the molecular recognition principles in astrobiology

VM Kolb - Instruments, Methods, and Missions for Astrobiology …, 2013 - spiedigitallibrary.org
Principles of molecular recognition, which include both intra-and inter-molecular
noncovalent interactions, guide twoand three-dimensional organization of molecules which …