Systems biology in cardiovascular disease: a multiomics approach
Omics techniques generate large, multidimensional data that are amenable to analysis by
new informatics approaches alongside conventional statistical methods. Systems theories …
new informatics approaches alongside conventional statistical methods. Systems theories …
GTRD: an integrated view of transcription regulation
S Kolmykov, I Yevshin, M Kulyashov… - Nucleic acids …, 2021 - academic.oup.com
Abstract The Gene Transcription Regulation Database (GTRD; http://gtrd. biouml. org/)
contains uniformly annotated and processed NGS data related to gene transcription …
contains uniformly annotated and processed NGS data related to gene transcription …
The UCSC genome browser database: 2023 update
Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is an omics data
consolidator, graphical viewer, and general bioinformatics resource that continues to serve …
consolidator, graphical viewer, and general bioinformatics resource that continues to serve …
The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences
Y Perez-Riverol, J Bai, C Bandla… - Nucleic acids …, 2022 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data. PRIDE is …
the world's largest data repository of mass spectrometry-based proteomics data. PRIDE is …
[HTML][HTML] Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
M Guilliams, J Bonnardel, B Haest, B Vanderborght… - Cell, 2022 - cell.com
The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center
B Amos, C Aurrecoechea, M Barba… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB,
https://veupathdb. org) represents the 2019 merger of VectorBase with the EuPathDB …
https://veupathdb. org) represents the 2019 merger of VectorBase with the EuPathDB …
[HTML][HTML] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …
The evolution, evolvability and engineering of gene regulatory DNA
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
phenotype and fitness,–. Constructing complete fitness landscapes, in which DNA …
UniProt: the universal protein knowledgebase in 2021
Nucleic acids research, 2021 - academic.oup.com
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-
quality and freely accessible set of protein sequences annotated with functional information …
quality and freely accessible set of protein sequences annotated with functional information …
A compendium of uniformly processed human gene expression and splicing quantitative trait loci
N Kerimov, JD Hayhurst, K Peikova, JR Manning… - Nature …, 2021 - nature.com
Many gene expression quantitative trait locus (eQTL) studies have published their summary
statistics, which can be used to gain insight into complex human traits by downstream …
statistics, which can be used to gain insight into complex human traits by downstream …