Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Depression is the third leading cause of disability in the world. Depressive symptoms may
be reduced within several weeks after the start of conventional antidepressants, but …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

Abstract β-Site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the β-
secretase that initiates Aβ production in Alzheimer's disease (AD). BACE1 levels are …

Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels …

Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative
neurophysiological and neurocognitive endophenotypes with demonstrated deficits in …

The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising
developments for the treatment of depression. Nevertheless, racemic ketamine and (S) …

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Thiazolidinediones (TZDs) are agonists at peroxisome proliferator-activated gamma-type
(PPAR-γ) receptors and are used clinically for the treatment of type 2 diabetes where they …