Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal transduction and targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales

AE El‐Kenawi, AB El‐Remessy - British journal of …, 2013 - Wiley Online Library
Angiogenesis, a process of new blood vessel formation, is a prerequisite for tumour growth
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …

Clinical update on cancer: molecular oncology of head and neck cancer

Y Suh, I Amelio, T Guerrero Urbano, M Tavassoli - Cell death & disease, 2014 - nature.com
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are
biologically aggressive in nature. These cancers remain difficult to treat and treatment can …

Current treatment options for metastatic head and neck cancer

KAR Price, EE Cohen - Current treatment options in oncology, 2012 - Springer
Opinion statement Head and neck squamous cell carcinoma is now the 8th most common
cancer affecting men in the United States largely due to a rising epidemic of oropharynx …

[HTML][HTML] EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling

S Sato, S Vasaikar, A Eskaros, Y Kim, JS Lewis… - JCI insight, 2019 - ncbi.nlm.nih.gov
Angiogenesis is a key process that allows nutrient uptake and cellular trafficking and is
coopted in cancer to enable tumor growth and metastasis. Recently, extracellular vesicles …

Progress in targeted therapeutic drugs for oral squamous cell carcinoma

L Liu, J Chen, X Cai, Z Yao, J Huang - Surgical oncology, 2019 - Elsevier
With the rapid development of biomedicine, people have a deeper understanding with the
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …

A review on the advances and challenges of immunotherapy for head and neck cancer

G Cheng, H Dong, C Yang, Y Liu, Y Wu, L Zhu… - Cancer Cell …, 2021 - Springer
Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …

Phase III randomized trial of chemotherapy with or without bevacizumab in patients with recurrent or metastatic head and neck cancer

A Argiris, S Li, P Savvides, JP Ohr, J Gilbert… - Journal of Clinical …, 2019 - ascopubs.org
PURPOSE We evaluated the addition of bevacizumab, a humanized monoclonal antibody
that targets vascular endothelial growth factor, to platinum-based chemotherapy in recurrent …

Anlotinib for previously treated advanced or metastatic esophageal squamous cell carcinoma: a double‐blind randomized phase 2 trial

J Huang, J Xiao, W Fang, P Lu, Q Fan, Y Shu… - Cancer …, 2021 - Wiley Online Library
Background Currently, there are no randomized trials on the effect of antiangiogenic therapy
in patients with esophageal squamous cell carcinoma (ESCC). The following study …

[HTML][HTML] Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck

A Argiris, AP Kotsakis, T Hoang, FP Worden… - Annals of oncology, 2013 - Elsevier
Background We evaluated combined targeting with cetuximab, an anti-epidermal growth
factor receptor (EGFR) monoclonal antibody, and bevacizumab, an anti-vascular endothelial …