Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales
AE El‐Kenawi, AB El‐Remessy - British journal of …, 2013 - Wiley Online Library
Angiogenesis, a process of new blood vessel formation, is a prerequisite for tumour growth
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …
Clinical update on cancer: molecular oncology of head and neck cancer
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are
biologically aggressive in nature. These cancers remain difficult to treat and treatment can …
biologically aggressive in nature. These cancers remain difficult to treat and treatment can …
Current treatment options for metastatic head and neck cancer
KAR Price, EE Cohen - Current treatment options in oncology, 2012 - Springer
Opinion statement Head and neck squamous cell carcinoma is now the 8th most common
cancer affecting men in the United States largely due to a rising epidemic of oropharynx …
cancer affecting men in the United States largely due to a rising epidemic of oropharynx …
[HTML][HTML] EPHB2 carried on small extracellular vesicles induces tumor angiogenesis via activation of ephrin reverse signaling
S Sato, S Vasaikar, A Eskaros, Y Kim, JS Lewis… - JCI insight, 2019 - ncbi.nlm.nih.gov
Angiogenesis is a key process that allows nutrient uptake and cellular trafficking and is
coopted in cancer to enable tumor growth and metastasis. Recently, extracellular vesicles …
coopted in cancer to enable tumor growth and metastasis. Recently, extracellular vesicles …
Progress in targeted therapeutic drugs for oral squamous cell carcinoma
L Liu, J Chen, X Cai, Z Yao, J Huang - Surgical oncology, 2019 - Elsevier
With the rapid development of biomedicine, people have a deeper understanding with the
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …
biological characteristics of malignant tumors, and begin to notice that in most tumors, there …
A review on the advances and challenges of immunotherapy for head and neck cancer
G Cheng, H Dong, C Yang, Y Liu, Y Wu, L Zhu… - Cancer Cell …, 2021 - Springer
Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …
Phase III randomized trial of chemotherapy with or without bevacizumab in patients with recurrent or metastatic head and neck cancer
PURPOSE We evaluated the addition of bevacizumab, a humanized monoclonal antibody
that targets vascular endothelial growth factor, to platinum-based chemotherapy in recurrent …
that targets vascular endothelial growth factor, to platinum-based chemotherapy in recurrent …
Anlotinib for previously treated advanced or metastatic esophageal squamous cell carcinoma: a double‐blind randomized phase 2 trial
J Huang, J Xiao, W Fang, P Lu, Q Fan, Y Shu… - Cancer …, 2021 - Wiley Online Library
Background Currently, there are no randomized trials on the effect of antiangiogenic therapy
in patients with esophageal squamous cell carcinoma (ESCC). The following study …
in patients with esophageal squamous cell carcinoma (ESCC). The following study …
[HTML][HTML] Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck
A Argiris, AP Kotsakis, T Hoang, FP Worden… - Annals of oncology, 2013 - Elsevier
Background We evaluated combined targeting with cetuximab, an anti-epidermal growth
factor receptor (EGFR) monoclonal antibody, and bevacizumab, an anti-vascular endothelial …
factor receptor (EGFR) monoclonal antibody, and bevacizumab, an anti-vascular endothelial …