Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

Abstract Amyotrophic Lateral Sclerosis (ALS) is an inexorably progressive
neurodegenerative condition with no effective disease modifying therapies. The …

Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Frontotemporal dementia (FTD) phenotypes have distinctive and well-established cortical
signatures, but their subcortical grey matter profiles are poorly characterised. The …

Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …