The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

Ionizing radiation (IR) damages DNA and other macromolecules, including proteins and
lipids. Most cell types can repair DNA damage and cycle continuously their macromolecules …

Lens opacities or cataract (s) represent a universally important cause of visual impairment
and blindness. Typically, cataract is acquired with aging as a complex disorder involving …

Purpose The antioxidant enzymes pathway is considered the most important pathway
involved in the repair of reactive oxygen species (ROS)–induced damage. Therefore, we …

Ionizing radiation is a proven human carcinogen and cataractogen. The crystalline lens of
the eye is among the most radiosensitive tissues in the body. A clouding of the normally …

Because of the increasing application of ionizing radiation in medicine, quantitative data on
effects of low-dose radiation are needed to optimize radiation protection, particularly with …

Purpose: The gene for Eph-receptor tyrosinekinase-type A2 (EPHA2) has been shown to be
involved in the pathogenesis of age-related cataract (ARC). The aim of this study was to …

The development of age-related cataract (ARC) is associated with DNA damage of the lens
epithelial cells (LECs). This study aimed to investigate the expression level of DNA repair …

Cancer is the leading cause of death in economically developed countries and the second
leading cause of death in developing countries. The relationship between genetic …

Cataracts are the major eye disorder and have been associated mainly with mutations in
lens-specific genes, but cataracts are also frequently associated with complex syndromes. In …